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Formation of venous collaterals and regeneration in the donor remnant liver: Volumetric analysis and three-dimensional visualization

: Schenk, A.; Hindennach, M.; Radtke, A.; Malago, M.; Schroeder, T.; Peitgen, H.-O.


Transplantation proceedings 41 (2009), Nr.6, S.2515-2517
ISSN: 0041-1345
Fraunhofer MEVIS ()

Purpose. We sought was to quantify and visualize the regeneration of the remnant liver after living donor liver transplantation using computed tomographic (CT) data. Methods. For the evaluation of preoperative and follow-up data, we developed a software assistant that was able to compute the volume growth of the remnant liver and liver territories as well as visualize the individual growth of hepatic vessels over time. The software was applied to CT data of 20 donors who underwent right hepatectomy including the middle hepatic vein with at least 3 follow-up examinations in the first year after transplantation. Results. After donation of a right lobe graft, the remnant liver regenerated by an average 77% of the original volume within the first 3 postoperative months and to 86% within the first year. The growth of the left lateral segments was increased compared with that of segment IV in all cases. The visualization showed the growth of the portal vein and the hepatic veins. With the simultaneous display of pre- and postoperative results, it was possible to detect the formation of collaterals between truncated segment IVb veins and the veins of segment IVa or of the left lateral lobe. Conclusion. The software-assisted analysis of follow-up data yielded additional insight into territorial liver regeneration after living donor liver transplantation and allowed for reliable detection of relevant hepatic vein collaterals using CT data.