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Journal Article
Titel
Development of a Multichannel Fluorescence Affinity Sensor System
Alternative
Fluorometric multichannel sensor for analysis of bioaffinity reactions
Abstract
A multichannel fluorometer is proposed for analysis of biochemical reactions. The sensor is based on the luminescence generation in the evanescent field of a totally reflected laser beam. For transduction, multiple reflection elements are used. Multichannel operation is realized, including the possibility of applying different solutions to each channel at the same time. First experimental results, obtained with fluorescein or Cy5 as labels in a model hybridization assay, demonstrate the applicability and allow the detection of 3−10 fmol injected fluorescently labeled oligonucleotide.
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