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Cystic squamous cell tumours in the lung of rats and Syrian hamsters induced by coal oven flue exhaust in combination with benzo(a)pyrene


Mohr, U.; Dungworth, D.L.; Brain, J.D.; Driscoll, K.E.; Grafström, R.C.; Harris, C.C. ; International Life Sciences Institute -ILSI-, Washington/D.C.:
Relationships between respiratory disease and exposure to air pollution
Washington: ILSI Press, 1998 (ILSI Monographs)
ISBN: 1-57881-015-9
International Inhalation Symposium <6, 1997, Hannover>
Conference Paper
Fraunhofer ITA ( ITEM) ()
adenocarcinoma; benzo(a)pyrene; rat; squamous cell tumor; syrian hamster

Rats and hamsters were exposed to coal oven flue exhaust. In addition, hamsters received intratracheal instillations of various doses of benzo(a)pyrene. In rats, the treatment resulted in the development of six cystic keratinizing squamous cell tumours (3 epitheliomas and 3 carcinomas), moderately keratinizing squamous cell carcinoma (12), as well as in the development of adenocarcinomas (2). In hamsters, five cystic keratinizing squamous cell carcinoma were observed.