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Carcinogenicity studies on natural and man made fibres with the intraperitoneal test in rats.

Kanzerogenitätsstudien von natürlichen und künstlichen Fasern im Intraperitonealtest bei Ratten
: Pott, F.; Ziem, U.; Reiffer, F.-J.; Bellmann, B.; Rosenbruch, M.; Huth, G.; Roller, M.

International Agency for Research on Cancer -IARC-, Lyon:
Non-occupational exposure to mineral fibres
Lyon, 1989 (IARC Scientific Publications 90)
ISBN: 92-832-1190-1
pp.173-179 : Abb.,Tab.,Lit.
Book Article
Fraunhofer ITA ( ITEM) ()
Asbest; carcinogen; Carcinogenesis; carcinogenicity testing; Faser; fiber; hazardous substance; intraperitoneal injection; Intraperitonealtest; Kanzerogenität; lung; mineral fiber; rat; Ratte; toxicology; tumor

Female Wistar rats were injected intraperitoneally (i.p.) with a suspension of 11 fibrous and 3 granular dusts. A dose of 0.25 mg actinolite or UICC chrysotile induced tumours of the peritoneum in more than 50% of the animals. Even 0.05 and 0.01 mg proved to be carcinogenic, although no adhesions of the abdominal organs could be observed. The findings are in conflict with the hypothesis that a scar is always the morphological precondition for the development of an asbestos-induced tumour. Actinolite injected i.p. in a solution of polyvinylpyridine-N-oxide gave a lowe tumour incidence than when suspended only in saline, possibly due to inactivation of the fibre surface. Persistent glass fibres were less effective than actinolite having as similar fibre size distribution. On the other hand, relatively thick basalt fibres and ceramic fibres gave higher tumour incidences than expected. Wollastonite fibres were not carcinogenic, probably because of their low durability. Large amounts of pol yvinylchloride, alpha-ferric oxide hydrate and wood dust also led only to adhesions of the abdominal organs and fibrosis; a definite carcinogenic effect was not detected.