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Carcinogenicity of cadmium chloride aerosols in W rats.

Krebserzeugung durch Cadmiumchlorid-Aerosole in Wistar Ratten
: Hochrainer, D.; Koenig, H.P.; Oberdoerster, G.; Oldiges, H.; Takenaka, S.

Journal of the National Cancer Institute 70 (1983), No.2, pp.367-373 : Abb.,Tab.,Lit.
ISSN: 0027-8874
Journal Article
Fraunhofer IUCT ( IME) ()
Cadmiumchlorid-Aerosol; Karzinom; Langzeitinhalation; Lungenkarzinom

Lung cancers were induced in inbred W rats by cadmium chloride aerosols. For 18 months, 120 male W rats were continuously exposed to cadmium chloride aerosols with cadmium (Cd) concentrations of 12.5, 25, and 50 myg/cubic meter, respectively. For the same period of time, 41 rats were kept in filtered air; these rats served as the control group. The survivors were killed 13 months after the end of the inhalation experiments. Histopathologic examination revealed a dose-dependent incidence of primary lung carcinoms of the following types: adenocarcinomas, epidermoid (squamous cell) carcinomas, combined epidermoid carcinomas and adenocarcinomas, and mucoepidermoid carcinomas. The incidence of lung carcinomas was 71.4% in the group exposed to 50 myg Cd/cubic meter, 52.6% in the group exposed to 25 myg Cd/cubic meter, and 15.4% in the group exposed to 12.5 myg Cd/cubic meter. None of the controls developed lung carcinomas. At the end of the experiment, the remaining Cd concentrations in the lungs were relatively high, almost at the same level as those in the livers. (ITA)