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Carcinogenic effects of solid particles

Abstract
 
: Heinrich, U.

Medizinische Hochschule Hannover; International Life Sciences Institute -ILSI-, Washington/D.C.; Fraunhofer-Institut für Toxikologie und Aerosolforschung -ITA-, Hannover:
Toxic and carcinogenic effects of solid particles in the respiratory tract. Abstracts : 4th International Inhalation Symposium, Hannover
Hannover, 1993
pp.43
International Inhalation Symposium <4, 1993, Hannover>
International Symposium on Inhalation Toxicology <4, 1993, Hannover>
Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract <1993, Hannover>
English
Conference Paper
Fraunhofer ITA ( ITEM) ()
aluminum oxide; carbon; carbon-black; carcinogene; Carcinogenesis; carcinogenicity testing; diesel motor exhaust gas; diesel soot; ferric oxide; inhalation toxicology; lung; lung tumor; particle; polycyclic aromatic hydrocarbon; rat; respiratory organ; titanium dioxide; toxicology; toxicology-experimental; tumor

Abstract
The co-carcinogenic effect of intratracheally (i.tr.) administered nuisance particulates like titanium dioxide, carbon, ferric oxide or aluminum oxide was already demonstrated in hamsters almost 20 years ago. Particle-related lung tumors in rats were reported for the first time after inhalation exposure to 200 mg/m3 coal dust. A similar tumor response occured after inhalation of 250 mg/m3 TiO2 and after i.tr. instillation of 10 mg of activated carbon. Since the unexpected high incidence of lung tumors found in rats exposed to diesel engine exhaust could not be explained solely by the low content of carcinogenic polycyclic aromatic hydrocarbons of diesel soot, the hypothesis was generated that the carbonaceous core of diesel soot might be responsible for the diesel exhaust-related tumor response. This hypothesis proved to be right when rats exposed to 6 mg/m3 carbon black particles, almost completely devoid or organic material for 10 months, also developed lung tumors.

: http://publica.fraunhofer.de/documents/PX-7269.html