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Oxygenatormembran

Oxygenator membrane for use e.g. in heart operations, obtained by hydrolytic condensation of mixture containing organosilane with polymerizable double bonds, then processing as film and hardening, e.g. by irradiation.
 
: Wolter, H.; Ballweg, T.; Storch, W.

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Frontpage ()

DE 1998-19841439 A1: 19980910
DE 1999-19932628 A: 19990713
EP 1999-113689 A: 19990715
DE 19932628 A1: 20000316
EP 985442 A2: 20000315
A61M0001
B01D0071
German
Patent, Electronic Publication
Fraunhofer ISC ()

Abstract
Die Erfindung betrifft eine Oxygenatormembran auf der Basis von organisch modifizierten Kieselsaeurepolykondensaten und ein Verfahren zu deren Herstellung. Die Oxygenatormembran ist dadurch erhaeltlich, dass man eine viskose bis harzartige Fluessigkeit nach ueblichen Methoden zu einer Membran verarbeitet, diese gegebenenfalls trocknet und thermisch und/oder strahlungsinduziert und/oder chemisch induziert haertet. Die viskose bis harzartige Fluessigkeit wird erhalten a) durch hydrolytische Polykondensation von einer oder mehreren Verbindungen der allgemeinen Formel I und/oder II und/oder III und/oder IV und/oder von diesen durch hydrolytische Kondensation abgeleiteten Vorkondensaten und gegebenenfalls von einer oder mehreren Verbindungen der allgemeinen Formel V, und gegebenenfalls b) durch Zugabe von einem oder mehreren copolymerisierbaren und/oder (poly)addierbaren Monomeren und/oder Oligomeren und/oder von einem oder mehreren Haertungskatalysatoren. $F1

 

EP 985442 A UPAB: 20000419 NOVELTY - Oxygenator membranes are produced by processing a liquid obtained by hydrolytic condensation of hydrolyzable organo-silanes with polymerizable unsaturated groups and/or hydrolyzable organo-silanes with other functions such as mercapto groups and then hardening the resulting film. DETAILED DESCRIPTION - Oxygenator membranes, obtained by processing a slightly viscous to resinous liquid to form a membrane which is optionally dried and then subjected to thermal and/or radiation-induced and/or chemically-induced hardening. The liquid used is obtained (a) by hydrolytic polycondensation of compound(s) of formula (I) and/or (II) and/or (III) and/or (IV) and/or from precondensates derived from (I)-(IV) and optionally from compounds of formula (V) and/or precondensates derived from these, carried out by addition of water or moisture, in the presence or absence of solvent and/or condensation catalyst, using a mol ratio of (I + II + III + IV):(V) = (1:0)-(1:20), and optionally (b) with the addition of monomer(s) and/or oligomer(s) which is/are copolymerisable and/or suitable for (poly)addition reactions and/or with the addition of hardening catalyst(s). R = 1-15C alkyl, alkenyl, aryl, alkaryl or aralkyl, optionally containing oxygen or sulfur atoms and/or ester, carbonyl, carboxyl, amine and/or amino groups; R1, R2 = 0-15C alkylene, arylene, arylene-alkylene or alkylene-arylene, all optionally modified as for R; R3 = H, -R2-R1-R4-SiXxR3-x, carboxyl or a group R as defined above; R4 = -(CHR6CHR6)n-, -CHR6CHR6-S-R5-, -CO-S-R5-, -CHR6CHR6-NR6-R5-, -Y-CS-NH-R5-, -S-R5-, -Y-CONH-R5-, -COOR5-, -Y-CO-C2H3(COOH)-R5-, -Y-CO-C2H3(OH)-R5- or -CO-NR6-R5-; R5 = as for R1 and R2, but with 1-15C atoms; R6 = H, or 1-10C alkyl or aryl; R7 = H or a group as defined for R; X = H, halogen, hydroxy, alkoxy, acyloxy, alkylcarbonyl, alkoxycarbonyl or NR2; R = H, alkyl or aryl; Y = -O-. -S- or -NR6-; Z = -O- or -(CHR6)m-; m = 1 or 2; a = 1, 2 or 3, with b = 1 for a = 2 or 3; b = 1, 2 or 3, with a = 1 for b = 2 or 3; c = 1-6; x = 1, 2 or 3; (a+x) = 2, 3 or 4. In (II), B = a 4-50C linear or branched organic residue with at least one C=C double bond; R = as in (I); R3 = 0-10C alkylene, arylene, arylene-alkylene or alkylene-arylene, optionally with in-chain O, S or amino groups; X = as in (I), but with R = H, alkyl, aryl or alkylaryl; A = (a) O, S or NH for d = 1, Z = CO, R1 = 1-10C alkylene, arylene or alkylene-arylene (optionally with in-chain O, S or amino) and R2 = COOH or H, or (b) O, S, NH or COO for d = 1, Z = CHR' (with R' = H, alkyl, aryl or aralkyl), R1 as in (a) and R2 = OH, or (c) O, S, NH or COO for d = 0, R1 as in (a) and R2 = OH, or (d) S, for d = 1, Z = CO, R1 = N and R2 = H; a = 1, 2 or 3; b = 0, 1 or 2; (a+b) = 3; c = 1, 2, 3 or 4. ((HS-R5)nR6-S-E-R5)aSixR4-a-x (IV') A = O, S, PR, POR, NHCOO or NHCONR; B = a linear or branched organic residue derived from a 5-50C compound B' with at least one C=C double bond (if c = 1 and A = NHCOO or NHCONR) or at least two C=C bonds; R = as in (I); R' = alkylene, arylene or alkylene-arylene; R = H, alkyl, aryl or alkylaryl; X = as in (II); a = 1, 2 or 3; b = 0, 1 or 2; c = 0 or 1; x = a whole number, the value of which equals the number of double bonds in compound B' minus 1 or the number of double bonds in B', if c = 1 and A = NHCOO or NHCONR; alkyl/alkenyl = optionally substituted 1- or 2-20C linear, branched or cyclic groups; aryl = optionally substituted phenyl, naphthyl or biphenyl; other groups (alkoxy, acyloxy, alkylcarbonyl, alkoxycarbonyl, alkylaryl, aralkyl, arylene, alkylene and alkylene-aryl) = groups derived from alkyl and aryl groups as defined above . In (IV), R = as in (I); X = as in (II); Y = an organic residue with 1-30 (preferably 1-20) C atoms and 1-5 (preferably 1-4) mercapto groups; a, x = 1, 2 or 3; (a+x) = 2, 3 or 4 . In (V), R = as in (I); X = as in (II); a = 1, 2 or 3. An INDEPENDENT CLAIM is also included for a process for the production of oxygenator membranes by preparation of a slightly viscous to resinous liquid as described above, followed by processing by conventional methods to form a membrane which is optionally dried and then hardened as above. USE - As membranes in blood-oxygenators for medical/surgical applications, e.g. in heart operations and in the treatment of certain pulmonary conditions. ADVANTAGE - Non-toxic membranes with high mechanical stability and with a gas permeability and flexibility which can be varied over a wide range. These membranes show high gas permeability values with no penetration of the fluid phase (even when unsupported), can be made by a simple, low-cost process in the form of flat membranes or hollow fibres and can be modified during or after production as required, e.g. to prevent coagulation of blood or to adjust the polarity or adsorption properties of the membrane.

: http://publica.fraunhofer.de/documents/PX-63515.html