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  4. Basic fibroblast growth factor and transforming growth factor-alpha are hepatotrophic mitogens in vitro
 
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1990
Journal Article
Title

Basic fibroblast growth factor and transforming growth factor-alpha are hepatotrophic mitogens in vitro

Abstract
Basic fibroblast growth factor (bFGF) and transforming growth factor-Alpha (TGF Alpha) have been identified as potent hepatotrophic mitogens. bFGF and TGF Alpha induce DNA synthesis in fetal and adult rat hepatocytes in primary culture and support fetal rat hepatocyte muliplication in chemically defined medium. No additional exogenous growth or progression factors are required by the cells for traversing the cell cycle or for cell division. These mitogenic polypeptides, previouly identified in various cell types including liver and endothelial cell, platelets, and macrophages may act locally in a paracrine mode in controlling hepatocyte multiplication in the liver during development and regeneration.
Author(s)
Hoffmann, B.
Paul, D.
Journal
Journal of Cellular Physiology  
DOI
10.1002/jcp.1041420118
Language
English
ITA  
Keyword(s)
  • basic fibroblast growth factor

  • bFGF

  • DNA synthesis

  • hepatocyte

  • hepatotrophic

  • mitogen

  • rat

  • TFG alpha

  • transforming growth factor alpha

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