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Antimutagenic action of tumor promoters and co-mutagenic action of co-carcinogens in yeast and mice

: Fahrig, R.

Shankel, D.M.:
Antimutagenesis and anticarcinogenesis mechanism
New York: Plenum Press, 1986
pp.552 ff
Book Article
Fraunhofer ITA ( ITEM) ()
antimutagenic; co-carcinogen; co-mutagenic; mouse; tumor promoter; yeast

In experiments with yeast strain MP1, co-carcinogens were found to be co-mutagenic and antirecombinogenic, tumor promoters to be co-recombinogenic and antimutagenic. Substances that were co-carcinogens as well as tumor promoters had an intermediary effect. Bile acids showed all three possible ways of action supporting the hypothesis that mutagenesis is the mechanism by which chemicals induce malignancy, and that co-carcinogens modify the process by enhancement of mutagenicity, whereas tumor promoters effect carcinogenesis by increase of the spontaneous frequency of recombination. These results were confirmed in the mammalian spot test, by in vivo treatment of mice with the following: (a) the co-carcinogens catechol and hydroquinone, (b) the tumor promoter and co-carcinogen TPA, and (c) the tumor promoter limonene. Carcinogen-induced recombination due to mitotic crossing over and that due to gene mutations were reduced and enhanced, respectively.