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Verfahren und Vorrichtung zur quantitativen und qualitativen on-line-Differenzierung von biotischen und abiotischen Partikeln

On-line differentiation of abiotic and biotic particles in a gaseous medium - by measuring the number and size of particles present twice with an intermediate heating step, useful for assessing contamination during e.g. medicine production.
: Koelblin, R.; Grimme, R.

Frontpage ()

DE 1997-19717749 A: 19970421
DE 1997-19717749 A: 19970421
EP 1998-919275 A: 19980416
DE 19717749 A1: 19981022
EP 977980 B1: 20030226
Patent, Electronic Publication
Fraunhofer IPA ()

Process for quantitative and qualitative on-line differentiation of biotic and abiotic particles in a gaseous medium is claimed. The number and size of particles is determined in a first measuring device and then the medium is heated for a short time to above 100 deg. C. The measurements are then repeated in a second measuring device. The number and size of biotic and abiotic particles is then determined based on the two results. Preferably the medium is heated for a few seconds to above 200 deg. C especially above 400 deg. C. In addition to the particle size distribution, other physical parameters e.g. the refractive index of the particles are determined simultaneously e.g. by light scattering. USE - Method is useful for assessing particulate contamination in gaseous media especially where the production environment plays an important role in determining the product quality. Such measurements are useful in medicines, foods, biotechnology, in health service work and in monitoring maxim um allowable concentrations in the workplace. The biotic particles may be alive or dead and include microorganisms (such as fungi or bacteria), their fragments, skin flakes, production residues, or plant spores as well as hair, sweat or skin fats. ADVANTAGE - The process provides rapid results and is suitable for continuous on-line usage. The results show a high degree of reproducibility and the process permits a high degree of automisation. The operation is simplified compared with prior art processes.