Varianten des humanen rekombinanten Interferon-gamma (rhu-IFN-gamma) mit erhoehter thermischer Stabilitaet (A1)

Thermostable recombinant human interferon gamma variants - useful in medicine, e.g. to treat kidney tumours, and research

Abstract
Polypeptide having the amino acid sequence (I) (optionally C-terminally truncated by 1-10 residues), is new, Met-Gln-Asp-Pro-Tyr-Val-Lys-(Glu/Cys)aa-Ala-Glu-Asn-Leu Lys-Lys-Tyr-Phe-Asn-(Ala/Cys)ba-Gly-His-Ser-Asp-Val-Ala Asp-Asn-Gly-Thr-Leu-Phe-Leu-Gly-Ile-Leu-Lys-Asn Trp-Lys-Glu-Glu-Ser- Asp-Arg-Lys-Ile-Met-Gln-Ser (Gln/Cys)da-Ile-Val-Ser-Phe-Tyr-Phe-Lys- Leu-Phe-Lys-Asn Phe-Lys-Asp-Asp-Gln-Ser-Ile-Gln-Lys-(Ser/Cys)ab-Val- Glu Thr-Ile-Lys-Glu-Asp-Met-Asn-Val-(Lys/Cys)ca-Phe-Phe-Asn Ser-Asn-Lys-Lys-Lys-Arg-Asp-Asp-Phe-Glu-Lys-(Leu/Cys)db Thr-Asn-Tyr-Ser-Val-Thr-Asp-Leu-Asn-Val-Gln-Arg Lys-Ala-Ile- (His/Cys)bb-Glu-Leu-Ile-Gln-Val-Met-Ala-Glu (Leu/Cys)cb-Ser-Pro-Ala- Ala-Lys-Thr-Gly-Lys-Arg-Lys-Arg Ser-Gln-Met-Leu-Phe-Arg-Gly-Arg-Arg- Ala-Ser-Gln (I), provided that at least 1 of (aa/ab), (ba/bb), (ca/cb) and (da/db) is (Cys/Cys). USE - The polypeptide and protein homodimer are thermostable variants of recombinant human interferon gamma (IFN gamma ), which are useful in medicine for treat ing kidney tumours, chronic granulomatosis or neurormatitis, and in research for measuring IFN levels and for stimulating cell cultures.