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Varianten des humanen rekombinanten Interferon-gamma (rhu-IFN-gamma), Verfahren zu ihrer Herstellung und ihre Verwendung

Varianten des humanen rekombinanten Interferon-gamma (rhu-IFN-gamma) mit erhoehter thermischer Stabilitaet (A1)
Thermostable recombinant human interferon gamma variants - useful in medicine, e.g. to treat kidney tumours, and research
: Waschuetza, G.; Li, V.; Otto, B.

Frontpage ()

DE 1995-19535853 A: 19950918
DE 1995-19535853 A: 19950918
EP 1996-938915 AW: 19960815
WO 1996-DE1556 A: 19960815
DE 19535853 C2: 19990325
EP 851926 B1: 20030730
Patent, Electronic Publication
Fraunhofer IGB ()

Polypeptide having the amino acid sequence (I) (optionally C-terminally truncated by 1-10 residues), is new, Met-Gln-Asp-Pro-Tyr-Val-Lys-(Glu/Cys)aa-Ala-Glu-Asn-Leu Lys-Lys-Tyr-Phe-Asn-(Ala/Cys)ba-Gly-His-Ser-Asp-Val-Ala Asp-Asn-Gly-Thr-Leu-Phe-Leu-Gly-Ile-Leu-Lys-Asn Trp-Lys-Glu-Glu-Ser- Asp-Arg-Lys-Ile-Met-Gln-Ser (Gln/Cys)da-Ile-Val-Ser-Phe-Tyr-Phe-Lys- Leu-Phe-Lys-Asn Phe-Lys-Asp-Asp-Gln-Ser-Ile-Gln-Lys-(Ser/Cys)ab-Val- Glu Thr-Ile-Lys-Glu-Asp-Met-Asn-Val-(Lys/Cys)ca-Phe-Phe-Asn Ser-Asn-Lys-Lys-Lys-Arg-Asp-Asp-Phe-Glu-Lys-(Leu/Cys)db Thr-Asn-Tyr-Ser-Val-Thr-Asp-Leu-Asn-Val-Gln-Arg Lys-Ala-Ile- (His/Cys)bb-Glu-Leu-Ile-Gln-Val-Met-Ala-Glu (Leu/Cys)cb-Ser-Pro-Ala- Ala-Lys-Thr-Gly-Lys-Arg-Lys-Arg Ser-Gln-Met-Leu-Phe-Arg-Gly-Arg-Arg- Ala-Ser-Gln (I), provided that at least 1 of (aa/ab), (ba/bb), (ca/cb) and (da/db) is (Cys/Cys). USE - The polypeptide and protein homodimer are thermostable variants of recombinant human interferon gamma (IFN gamma ), which are useful in medicine for treat ing kidney tumours, chronic granulomatosis or neurormatitis, and in research for measuring IFN levels and for stimulating cell cultures.