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Urinary and faecal excretion of chrysen and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application

: Grimmer, G.; Brune, H.; Dettbarn, G.; Jacob, J.; Mohtashamipur, E.; Norpoth, K.; Wenzel-Hartung, R.; Heinrich, U.; Pott, F.

Archives of toxicology 62 (1988), pp.401-405
ISSN: 0340-5761
ISSN: 1432-0738
Journal Article
Fraunhofer ITA ( ITEM) ()
Ausscheidung; Chrysen; excretion(urinary and faecal); Metabolismus; polycyclic aromatic hydrocarbon; polyzyklischer aromatischer Kohlenwasserstoff; Ratte

The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4- position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.