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Ameloblastoma in a female Wistar rat

: Ernst, H.; Mirea, D.

Experimental and Toxicologic Pathology 47 (1995), No.5, pp.335-340
ISSN: 0940-2993
Journal Article
Fraunhofer ITA ( ITEM) ()
histology; mouth; rat; tumor; tumor pathology

A spontaneous ameloblastoma of the right mandible is described in a 120-week-old female Wistar rat. The tumour had a locally aggressive growth pattern and was histologically characterized by sheets and islands of odontogenic epithelium bounded by a palisaded layer of ameloblast-like cells. Because of multifocal keratinizing squamous metaplasia of the stellate reticulum tissue, the tumour was classified as an acanthomatous ameloblastoma. Cyst formation, areas of stromal hyalinization and enamel matrix-like inclusions were further characteristics of the neoplasm. The epithelial elements stained strongly positive for broad spectrum cytokeratins.