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Toxicokinetics of solid particles in chronic studies using diesel soot, carbon black, toner, titanium dioxide and quartz

 
: Muhle, H.; Bellmann, B.; Creutzenberg, O.

Mohr, U.; Dungworth, D.L.; Mauderly, J.L.; Oberdörster, G. ; Medizinische Hochschule Hannover; International Life Sciences Institute -ILSI-, Washington/D.C.; Fraunhofer-Institut für Toxikologie und Aerosolforschung -ITA-, Hannover:
Toxic and carcinogenic effects of solid particles in the respiratory tract
Washington, DC: ILSI Press, 1994 (ILSI Monographs)
ISBN: 0-944398-14-6
pp.29-41
Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract <1993, Hannover>
International Symposium on Inhalation Toxicology <4, 1993, Hannover>
International Inhalation Symposium <4, 1993, Hannover>
English
Conference Paper
Fraunhofer ITA ( ITEM) ()
carbon-black; diesel soot; experimental; hamster; inhalation toxicology; lung; mice; particle; quartz; rat; silica; titanium dioxide; toner; toxicity testing; toxicology

Abstract
During the past five years, various chronic inhalation studies with solid particles have been performed at the Fraunhofer-Institute of Toxicology and Aerosol Research (ITA) and at the Inhalation Toxicology Research Institute in Albuquerque, NM, USA (ITRI). The inhaled materials include titanium dioxide, carbon black, soot from diesel exhaust, toner for copy machines, and quartz. The objectives of this paper are presentation of retention data from three studies in a comparative manner, illustration of the relationship between lung burden and macrophage-mediated clearance, and presentation of a model by which an appropriate aerosol concentration can be selected for chronic studies.

: http://publica.fraunhofer.de/documents/PX-36753.html