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  4. A subchronic inhalation study of a special test toner in rats.
 
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1988
Journal Article
Title

A subchronic inhalation study of a special test toner in rats.

Other Title
Eine subchronische Inhalationsstudie mit einem Test-Toner an Ratten
Abstract
A subchronic inhalation study, using SPF, F-344 rats, was conducted for 6 hr/da, 5 da/wk for 13 weeks. The special test toner was enriched about 10-fold, respirably (ACGIH), relative to product. Nominal exposure levels were 0, 1.0, 4.0, 16.0 and 64 mg/cubic meter (0, 0.35, 1.4, 5.6 and 22.4 mg/cubic meter, respirable). The exposures were well-tolerated, with no unscheduled deaths. Significant findings were restricted to the high exposure groups. The MTD (pulmonary) was determined relative to a defined Maximum Functionally Tolerated Dose (MFTD). At the lower exposures, clearance measurements of toner and a spike of iron oxide (Fe-59) were essentially unchanged from controls. At 16 mg/cubic meter, slight effects were observed. At 64 mg/cubic meter, no appreciable toner clearance occured after 60 da exposure. The MFTD was deemed to be exceeded at 64 mg/cubic meter and 16 mg/cubic meter was chosen for the chronic study high concentration. (ITA)
Author(s)
Kilpper, R.
Creutzenberg, O.
Mermelstein, R.
Mohr, U.
Muhle, H.
Takenaka, S.
Journal
The Toxicologist  
Conference
Society of Toxicology (Annual Meeting) 1988  
Language
English
ITA  
Keyword(s)
  • Inhalation

  • Lunge

  • Toner für Kopiermaschinen

  • Toxikologie

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