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  4. Spontaneous cystic keratinizing epithelioma in the lung of a Sprague-Dawley rat
 
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1998
Journal Article
Title

Spontaneous cystic keratinizing epithelioma in the lung of a Sprague-Dawley rat

Abstract
A spontaneous cystic keratinizing epithelioma in the lung of a 704-days-old female Hsd:Sprague-Dawley rat is described. The rat has a white subpleural discoloration on 1 diaphragmatic lobe at necrospy. Microscopically, a central keratin mass, surrounded by a multilayered squamous epithelium of varying thickness, was found. In the periphery of the tumor, epithelial nests projected multifocally into the adjacent alveolar spaces. Immunohistochemical labeling of nuclei by PNAC (proliferating cell nuclear antigen) revealed proliferative activity in 1 or 2 peripheral cell layers in most locations. To the best of the authors' knowledge, this is the first report dealing with the morphological and immunohistochemical features of a spontaneous cystic keratinizing epithelioma in a rat.
Author(s)
Rittinghausen, S.
Kaspareit, J.
Journal
Toxicologic Pathology  
DOI
10.1177/019262339802600218
Language
English
ITA  
Keyword(s)
  • immunohistochemistry

  • lung

  • rat

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