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Significance of the biodurability of man-made vitreous fibres to risk assessment

: Muhle, H.; Bellmann, B.


Environmental Health Perspectives 105 (1997), Suppl. 5, pp.1045-1047
ISSN: 0091-6765
ISSN: 1078-0475
ISSN: 1552-9924
International Meeting on the Toxicology of Natural and Man Made Mineral Fibrous and Non-Fibrous Particles <6, 1996, Lake Placis/NY>
Conference Paper
Fraunhofer ITA ( ITEM) ()
carcinogenicity testing; Fibers; Health risk assessment; inhalation toxicology; intratracheal instillation; lung; Mineral fibers; rat; Silica, vitreous; toxicity testing

It is generally agreed that the biodurability of man-made vitreous fibers is a major factor for the characterization of potential health effects. As there is currently no standardization of experimental protocols to determine biodurability, the results of the clearance assays have not been used up to now for regulatory purposes. Methods used to analyze biodurability in animal models are short-term inhalational exposure and intratracheal instillation of rat respirable fibers. Both test methods have strengths and limitations for regulatory purposes. We outline recommended procedures for standardized biodurability assays that can be used to compare different fiber types. In animal experiments, biodurability is difficult to seperate from biopersistence, as mucociliary and macrophage-mediated clearance occur simultaneously with dissolution and disintegration. (Abstract truncated)