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Reversion of co-mutagenic into antimutagenic effects by metabolic activation

: Fahrig, R.

Mutagenesis 4 (1989), No.4, pp.315
ISSN: 0267-8357
ISSN: 1464-3804
Journal Article
Fraunhofer ITA ( ITEM) ()
carcinogen; Carcinogenesis; carcinogenicity; carcinogenicity testing; mutagenesis; tumor promoter

Previously, it has been shown that parallels exist between the effects of tumour promoters and co-carcinogens in specific genetic tests and their effects in carcinogenicity assays. While tumour promoters were antimutagenic and co-recombinogenic, cocarcinogens had the reverse effects. We have now examined a class of substances which are either tumour promoters or anticarcinogens in carcinogenicity tests, depending on the mouse strain used and age of the animals. In the genetic test without activation these substances were antimutagenic and co-recombinogenic. In the presence of activating S9-mix they showed co-mutagenic and antirecombinogenic effects. The parallels between the occurence of specific genetic effects and specific effects in carcinogenicity assays do not prove that a causal relationship exists between the two processes, but they offer at least plausible explanations for several contrasting results obtained from carcinogenicity experiments.