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Pulmonary lesions in Wistar rats associated with chronic inhalation of 4,4'-methylene-diphenyl-diisocyanate (MDI)

 

Mohr, U.; Dungworth, D.L.; Brain, J.D.; Driscoll, K.E.; Grafström, R.C.; Harris, C.C. ; International Life Sciences Institute -ILSI-, Washington/D.C.:
Relationships between respiratory disease and exposure to air pollution
Washington: ILSI Press, 1998 (ILSI Monographs)
ISBN: 1-57881-015-9
pp.320-324
International Inhalation Symposium <6, 1997, Hannover>
English
Conference Paper
Fraunhofer ITA ( ITEM) ()
4,4'-methylenediphenyldiisocyanate; rat

Abstract
Isocyanates are important primary material at the production of polyurethane plastics, varnishes and glues. Nearly 3 million tons of isocyanate are produced yearly worldwide.Isocyanate have a irritating effect on eyes and airways as well as a sensitizing effect on the respiratory tract (isocyanate asthma). Since the risks for human health resulted mainly from inhalation uptake, a long-term inhalation toxicity/carcinogenicity study sponsored by the Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit/Umweltbundesamt (FKZ 11606084) was performed. 320 female Wistar rats (Crl:[WI]BR) were allocated to 4 groups of 80 females each and exposed in 6 m³ whole body inhalation chambers on average 17 h/day, 5 day/week for upto 24 months to clean air or to 0.2, 0.7 and 2.1 mg/m³ of monomeric MDI (MMAD: 1.03-1.06) aerosol. In the following, the main histopathological findings of the carcinogenicity study are summarized with emphasis on the lungs.

: http://publica.fraunhofer.de/documents/PX-30211.html