Abstract
Pulmonary function measurements using the whole body plethysmograph were performed in rats exposed by inhalation to a special test toner at various concentrations. Chrystalline SiO2 as a positive and TiO2 as a negative control material for fibrogenic end point were also used. In two experiments, a long-term and a subchronic recovery study, the impact of the inhaled material on mechanical lung function was investigated and compared with BAL (bronchoalveolar lavage) and histopathological observations in the lungs.