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Morphology and histogenesis of squamous cell metaplasia of the rat lung after chronic exposure to a pyrolized pitch condensate and/or carbon black, or to combinations of pyrolized pitch condensate, carbon black and irritant gases


Experimental and Toxicologic Pathology 45 (1993), No.2/3, pp.135-144
ISSN: 0940-2993
Journal Article
Fraunhofer ITA ( ITEM) ()
carbon-black; carcinogen; carcinogenicity; electron microscopy; experimental; histochemistry; histology; inhalation toxicology; keratin; lung; metaplasia; pathology; polycyclic aromatic hydrocarbon; rat; squamous cell metaplasia; testing

Female Wistar rats were exposed to different concentrations of a pyrolized pitch condensate and/or carbon black particles and/or a combination of irritant gases for 18 hours/day, 5 days/week for 10 months, followed by a clean air period of up to 20 months. Bronchiolo-alveolar hyperplasia and squamous metaplasia were important components of the resulting lesions. Squamous metaplasia and associated hyperplasia was investigated by routine histology, scanning and transmission electron microscopy, and by immunohistochemical detection of various cytokeratins (CK). Intensely CK positive squamous metaplasia lacking a distinct stratum spinosum was distinguishable from squamous metaplasia with a distinct stratum spinosum that reacted weakly CK positive or CK negative.