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Morphological effects of nickel powders on the lung of Syrian golden hamsters

: Bellmann, B.; Creutzenberg, O.; Mohr, U.; Muhle, H.; Takenaka, S.

Journal of Aerosol Science 19 (1988), No.7, pp.1149-1152 : Abb.,Lit.
ISSN: 0021-8502
Journal Article
Fraunhofer ITA ( ITEM) ()
Goldhamster; Inhalation; lung; nickel; nickel compound; nickelverbindung; PAP; proteinosis; pulmonary alveolar proteinosis; Syrian golden hamster

Syrian golden hamsters were treated by intratracheal instillation and received 0,8 mg nickel powder and 1,2 mg abrasive every two weeks for 6 or 12 months. Hamsters were sacrificed at 6, 12, 18 and 24 months after the beginning of the experiment for morphological and analytical examinations. A time dependent development of pulmonary alveolar proteinosis was observed in treated hamsters.