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Morphological effects of nickel powders on the lung of Syrian golden hamsters

: Bellmann, B.; Creutzenberg, O.; Mohr, U.; Muhle, H.; Takenaka, S.

	Journal of Aerosol Science 19 (1988), No.7, pp.1149-1152 : Abb.,Lit. ISSN: 0021-8502

	English
	Journal Article
	Fraunhofer ITA ( ITEM) ()
	Goldhamster; Inhalation; lung; nickel; nickel compound; nickelverbindung; PAP; proteinosis; pulmonary alveolar proteinosis; Syrian golden hamster

Abstract
Syrian golden hamsters were treated by intratracheal instillation and received 0,8 mg nickel powder and 1,2 mg abrasive every two weeks for 6 or 12 months. Hamsters were sacrificed at 6, 12, 18 and 24 months after the beginning of the experiment for morphological and analytical examinations. A time dependent development of pulmonary alveolar proteinosis was observed in treated hamsters.

: http://publica.fraunhofer.de/documents/PX-25137.html