• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Macrophage precursors as natural killer cells against tumor cells and microorganisms
 
  • Details
  • Full
Options
1988
Journal Article
Title

Macrophage precursors as natural killer cells against tumor cells and microorganisms

Abstract
Macrophage precursor cells have been isolated from spleen and liver of mice and have characterized using F4/80 antibody, their proliferative response to CSF-1 and their maturation to macrophages. These nonadherent and nonphagocytic cells exert strong killing of Yac-1 tumor cellx and of various microorganims. Transplantation of these macrophage precursors into lethally irradiated allogenic hosts restores natural killer (NK) activity within 14 days. Macrophage precursors show enhanced NK activity when activated with interleukin 2. FACS analysis of F 4/80 presorted macrophage precursors reveals about 30% of the cells coexpressing NK 1.1. and F 4/80. These data support the assumption that at least a part of the NK cell compartment is derived from the myeloid lineage.
Author(s)
Baccarini, M.
Decker, T.
Hao, L.
Lohmann-Matthes, M.-L.
Journal
Natural immunity and cell growth regulation  
Language
English
ITA  
Keyword(s)
  • candida albican

  • colony stimulating factor

  • CSF

  • hematopoietic stem cell

  • IL-2

  • immunology

  • interleukin-2

  • liver

  • macrophage

  • macrophage precursor

  • microorganism

  • natural killer cell

  • tumor cell

  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024