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  4. Macrophage precursor cells produce perforin and perform yac-1 lytic activity in response to stimulation with interleukin-2
 
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1994
Journal Article
Title

Macrophage precursor cells produce perforin and perform yac-1 lytic activity in response to stimulation with interleukin-2

Abstract
Macrophage precursor cells, derived from mouse bone marrow culture with granulocyte-macrophage colony-stimulating factor or colony-stimulating factor 1 (CSF- 1) as growth factor and interleukin-2 (IL-2) as stimulating factor, were activated by IL-2 to exert strong cytolytic activity against Yac-1 cells. In response to IL-2 stimulation these bone marrow macrophage precursor cells produced perforin as lytic molecules. The purity of the precursor cells for the study was proved as homogeneous positivity for Mac-1, NK-1.1 and negativity for Lyt 1 and 2. The cells express CSF-1 receptors on their surface, are able to proliferate and differentiate into typical macrophages when stimulated with CSF-1, and are therefore members of the macrophage lineage.
Author(s)
Li, H.
Pohler, U.
Strehlow, I.
Hertig, S.
Baccarini, M.
Emmendörffer, A.
Tschopp, J.
Lohmann-Matthes, M.-L.
Journal
Journal of Leukocyte Biology  
Language
English
ITA  
Keyword(s)
  • bone marrow

  • cell

  • cytology

  • immunochemistry

  • immunology

  • interleukin

  • macrophage

  • mouse

  • perforin

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