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Lung tumours in rats after intratracheal instillation of dusts


The Annals of occupational hygiene 38 (1994), No.1, pp.357-363
ISSN: 0003-4878
ISSN: 1475-3162
International Symposium on Inhaled Particles <1996, Great Britain>
Conference Paper
Fraunhofer ITA ( ITEM) ()
carbon black; carcinogen; carcinogenicity testing; diesel soot; dust; fiber; inhalation toxicology; intratracheal instillation; lung; lung tumor; mineral fiber; polycyclic aromatic hydrocarbon; rat; silica; tumor

Intratracheal instillation of several non-fibrous dusts induced tumour rates of between 3 and 65 per cent in female Wistar rats. Diesel soot showed a relatively high tumourigenic potency. However, carbon black with a high specific surface area and an extremely low PAH content was just as carcinogenic. The surface properties of elemental carbon seem to be much more effective than dusts from iron oxides, titanium dioxide and silicon carbide. There are indications of a rat specific overload carcinogenesis, but this term may oversimplify a mechanism which does not seem to exist in hamsters. Polyvinylpyridine-N-oxide inhibited the development of severe silicosis after treatment with quartz DQ 12 and prolonged the life-span: the total tumour incidence and especially the rate of malignant tumours increased. This supports the assumption that benign lung tumours, which seldom occur in humans are, in animals, precursors of malignant tumours and should be combined for toxicologic evaluation.