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Liver-associated macrophage precursor cells proliferate under impairment of regular hemopoiesis

: Decker, T.; Lohmann-Matthes, M.-L.

European Journal of Immunology 18 (1988), No.5, pp.697-703
ISSN: 0014-2980
ISSN: 1521-4141
Journal Article
Fraunhofer ITA ( ITEM) ()
colony stimulating factor; CSF; cytology; flow cytometry; hematopoiesis; hematopoietic stem cell; hemopoiesis; immunology; liver macrophages; macrophage precursor cell; proliferation

We reported previously that immature macrophage precursor cells can be isolated from spleen and liver of cyclophosphamide or pyran copolymer-pretreated mice. We now extended our investigations to livers of normal, untreated specific pathogen-free mice. Using the response to the macrophage growth factor colony stimulating factor-1 (CSF-1) and the presence of the mouse macrophage-specific F4/80 antigen as criteria of definition, in the liver of normal we could demonstrate macrophage precursor cells by means of proliferation assays and flow cytometric analysis.