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  4. Investigations on health-related properties of two sepiolite samples
 
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1997
Journal Article
Title

Investigations on health-related properties of two sepiolite samples

Abstract
Published ip injection studies have shown different biological behaviour of different sepiolite samples. There was no evidence for carcinogenic potential of sepiolite from Vicalvaro, Spain, whereas a high tumor incidence was reported for sepiolite from Finland. The low biological activity of sepiolite from Vicalvaro, compared to the Finnish sample, could be caused by low in vivo persistence or by the short length of the fibers, or both. In this study a further sepiolite sample, obtained as a commercial sample originating from China, was investigated. This sample contained a higher fraction of fibers longer than 5 um, comparable to the Finnish sepiolite sample. The fraction of fibers with a length >5 um was 0.12 and 2.2% for the Vicalvaro and Chinese sepiolite, respectively. (Abstract truncated)
Author(s)
Bellmann, B.
Muhle, H.
Ernst, H.
Journal
Environmental Health Perspectives  
Conference
International Meeting on the Toxicology of Natural and Man Made Mineral Fibrous and Non-Fibrous Particles 1996  
Open Access
DOI
10.2307/3433508
Additional full text version
Landing Page
Language
English
ITA  
Keyword(s)
  • carcinogenicity testing

  • histochemistry

  • histology

  • intraperitoneal injection

  • lung

  • magnesium

  • Mineral fibers

  • pathology

  • rat

  • Sepiolite

  • silicates

  • Tumors

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