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Induction or suppression of SV40 amplification by genotoxic carcinogens, non-genotoxic carcinogens of tumor promoters

: Fahrig, R.; Steinkamp-Zucht, A.


Mutation research 356 (1996), No.2, pp.217-224
ISSN: 0027-5107
Journal Article
Fraunhofer ITA ( ITEM) ()
carcinogen; Carcinogenesis; gene amplification; genetic recombination; genetic toxicology; mutagen; mutagenesis; mutation; oncogene; simian virus; SV40; toxicity testing

Carcinogens are generally classified into two Groups: genotoxic and non-genotoxic. As the final product of genotoxic and non-genotoxic carcinogens is the same, i.e., a clone of genetically altered cells, it could be possible that non-genotoxic carcinogens may yield genotoxic events as a secondary result of cell toxicity having led to mitogenesis/cellular proliferation, or that genetic alterations are induced that are normally negelected in genotoxicity tests. A genetic effect with possbile relevance for the ultimate mechanism of carcinogenicity is the amplification of oncogenes. In the present experiments, amplification of SV40-virus DNA in transformed CO 631-cells has been measured. In this system, two genotoxic carcinogens (positive control), two non-carcinogens (negative control), and eight non-genotoxic carcinogens have been tested.