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Induction of malignant peripheral nerve sheath tumors in European hamsters with 1,1-Dimethylhydrazine (UDMH)

: Ernst, H.; Rittinghausen, S.; Wahnschaffe, U.; Mohr, U.

Cancer letters 35 (1987), No.3, pp.303-311
ISSN: 0304-3835
ISSN: 1872-7980
Journal Article
Fraunhofer ITA ( ITEM) ()
Hamsters; histology; Nerves; nervous system; Tumors

A rate of up to 43 per cent of malignant peripheral nerve sheath tumors (PNST) was induced in Europaen hamsters (EH) after weekly s.c. administration of 1,1-Dimethylhydrazine (UDMH). The overall neoplastic response in the treated EH was also elevated as compared to the untreated controls. Histologically, the malignant PNST were neurofibrosarcomas and melanotic as well as unpigmented schwannomas. The occurence of melanotic schwannomas is briefly discussed with regard to the histogenesis of this rare tumor type.