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  4. Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyromycin
 
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1988
Journal Article
Title

Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyromycin

Abstract
The oligosaccharide-anthracyclines, aclacinomycin A, marcellomycin and musettamycin, are potent inducers of erythroid differentiation in hemopoietic cell lines of rodent and human origin. The present studies revealed that pyrromycin, a closely related mono-saccharide-anthracycline, induced erythroid differentiation in Friend leukemia cells and in the human leukemia cell line K 562. Pyrromycin, marcellomycin and musettamycin, which possess an identical aglycone structure containing a Cl-hydroxyl group, exhibited relatively low optimal inductive concentrations. In contrast, the optimal inductive concentration of a aclacinomycin A, which lacks the Cl-hydroxyl group, was markedly higher, i.e., the differentiation inducing capacity was lower. It should be noted, however, that the yield of differentiated cells following treatment with the monosaccharide-anthracycline pyrromycin was distinctly lower than that after treatment with the oligo-saccharide-anthracyclines, aclacinomycin A, marcellom ycin or mussettamycin. Thus, our data indicate that the efficacy of anthracyclines to induce erythroid differentiation is related to a) the presence of a Cl-hydroxyl group in the aglycone and b) the presence of an oligosaccharide side chain.
Author(s)
Schäfer, A.
Marquardt, H.
Steinheider, G.
Westendorf, J.
Journal
Cell Biology and Toxicology  
Language
English
ITA  
Keyword(s)
  • anthracycline

  • cell line

  • DNA

  • erythroid differentiation

  • hemopoietic cell line

  • leukemia cell

  • pyrromycin

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