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Immunmodulierende Wirkung von lysierten, immunaktiven Fraktionen aus ausgewählten Escherichia-coli-Stämmen auf das Makrophagensystem. Eine In-vitro Studie

Immunomodulating effect of lysed immunoactive fractions of selected Escherichia coli strains on macrophage system. In vitro study
: Hockertz, S.

Arzneimittel-Forschung 40 (1990), No.9, pp.1068-1072
ISSN: 0004-4172
Journal Article
Fraunhofer ITA ( ITEM) ()
bacterial infection; bakterielle Infektion; E.coli; Escherichia coli; immunaktive Fraktion; Immunmodulator; immunomodulator; lysed immunoactive fraction; macrophage; Makrophage; Uro-Vaxom

Immunomodulating Effect of Lysed Immunoactive Fractions of Selected Escherichia coli Strains on Macrophage System/In vitro study. The immunomodulator Uro-Vaxom (an immunoactive fraction of E. coli, FEC) is a therapeutic agent used to control bacterial infections. FEC was applied to macrophages of C57BL/6 mice to investigate the in vitro activation of these cells of the unspecific immune system. Experiments were designed to test the secretory, immunoregulatory and cytotoxic function of macrophages after application of FEC. As presented here, production of Interleukin-6 and tumor-necrosis-factor were significantly and dose-dependent way increased, whereas it was not possible to induce a secretion of Interleukin-1. In addition, FEC activated macrophages kill Leishmania donovani promastigotes. Candida albicans and Staphylococcus aureus. In comparison to a pressed echinaceae-preparation, FEC activated mouse macrophages secrete Interleukin-6 and tumor-necrosis-factor and kill protozoa, fungi and bacteria, with higher efficiency.