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IL-16 activates the SAPK signaling pathway in CD4+ macrophages

: Krautwald, S.

The Journal of immunology 160 (1998), No.12, pp.5874-5879
ISSN: 0022-1767
ISSN: 1048-3233
ISSN: 1047-7381
ISSN: 1550-6606
Journal Article
Fraunhofer ITA ( ITEM) ()
Activation, Enzyme; chemotaxis; cytokines; immunology; Interleukins; macrophages; protein kinase; T cells

IL-16 has been reported as a modulator of T cell activation and was shown to function as chemoattractant factor. The chemotactic activity of IL-16 depends on the expression of CD4 on the surface of target cells, but the intracellular signaling pathways are only now being deciphered. This report describes IL-16 as an additional activator of the stress-activated protein kinase (SAPK) pathway in CD4+ macrophages. Treatment of these cells with recombinant expressed IL-16 leads to the phosphorylation of SEK-1, resulting in activation of the SAPKs p46 and p54. IL-16 stimulation also leads to the phosphorylation of c-Jun and p38 MAPK (mitogen-activated protein kinase), without inducing MAPK- family members ERK-1 and ERK-2.