HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases

HLö 7 dimethanesulfonate (1-ÄÄÄ4-(aminocarbonyl)pyridinioÜ methoxyÜmethylÜ-2,4-bisÄ(hydroxyimino) methylÜpyridinium dimethansulfonate) is a broad-spectrum reactivator against highly toxic organophosphorus compounds. The compound was synthesized by a new route with the carcinogenic bis(chloromethyl)ether being substituted by the non-mutagenic bis(methylsulfonoxymethyl)ether. The very soluble dimethanesulfonate of obidoxime was also prepared by this way. HLö 7 dimethanesulfonate is the first water-soluble salt of HLö 7 that should be suitable for the wet/dry autoinjector technology, because aqueous solutions of HLö 7 are not very stable (calculated shelf-life 0.2 years when stored at 8 degree C, 1 M solution, pH 2.5).