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HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases

: Eyer, P.; Hagedorn, I.; Klimmek, R.; Lippstreu, P.; Löffler, M.; Spöhrer, U.; Steidl, I.; Szinicz, L.; Worek, F.; Oldiges, H.


Archives of toxicology 66 (1992), No.9, pp.603-621 : Abb.,Tab.,Lit.
ISSN: 0340-5761
ISSN: 1432-0738
Journal Article
Fraunhofer IUCT ( IME) ()
Acetylcholinesterase; HI 6; HLö 7; obidoxime; organophosphate; oxime; reactivation; Synthese; therapy

HLö 7 dimethanesulfonate (1-ÄÄÄ4-(aminocarbonyl)pyridinioÜ methoxyÜmethylÜ-2,4-bisÄ(hydroxyimino) methylÜpyridinium dimethansulfonate) is a broad-spectrum reactivator against highly toxic organophosphorus compounds. The compound was synthesized by a new route with the carcinogenic bis(chloromethyl)ether being substituted by the non-mutagenic bis(methylsulfonoxymethyl)ether. The very soluble dimethanesulfonate of obidoxime was also prepared by this way. HLö 7 dimethanesulfonate is the first water-soluble salt of HLö 7 that should be suitable for the wet/dry autoinjector technology, because aqueous solutions of HLö 7 are not very stable (calculated shelf-life 0.2 years when stored at 8 degree C, 1 M solution, pH 2.5).