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  4. HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases
 
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1992
Journal Article
Title

HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases

Abstract
HLö 7 dimethanesulfonate (1-ÄÄÄ4-(aminocarbonyl)pyridinioÜ methoxyÜmethylÜ-2,4-bisÄ(hydroxyimino) methylÜpyridinium dimethansulfonate) is a broad-spectrum reactivator against highly toxic organophosphorus compounds. The compound was synthesized by a new route with the carcinogenic bis(chloromethyl)ether being substituted by the non-mutagenic bis(methylsulfonoxymethyl)ether. The very soluble dimethanesulfonate of obidoxime was also prepared by this way. HLö 7 dimethanesulfonate is the first water-soluble salt of HLö 7 that should be suitable for the wet/dry autoinjector technology, because aqueous solutions of HLö 7 are not very stable (calculated shelf-life 0.2 years when stored at 8 degree C, 1 M solution, pH 2.5).
Author(s)
Eyer, P.
Hagedorn, I.
Klimmek, R.
Lippstreu, P.
Löffler, M.
Spöhrer, U.
Steidl, I.
Szinicz, L.
Worek, F.
Oldiges, H.
Journal
Archives of toxicology  
DOI
10.1007/BF01981499
Language
English
IUCT  
Keyword(s)
  • Acetylcholinesterase

  • HI 6

  • HLö 7

  • obidoxime

  • organophosphate

  • oxime

  • reactivation

  • Synthese

  • therapy

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