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Histological and ultrastructural alterations of the bronchioloalveolar region in the rat lung after chronic exposure to a pyrolized pitch condensate of carbon black, alone or in combination



Inhalation Toxicology 6 (1994), pp.459-483
ISSN: 0895-8378
ISSN: 1091-7691
Journal Article
Fraunhofer ITA ( ITEM) ()
bronchoalveolar lavage; carbon-black; inhalation toxicology; lung; lung diseases; lung tumor; pitch; rat

Morphological alterations in the bronchioloalveolar region of the rat lung were examined after chronic exposure to pyrolized pitch condensate or carbon black, alone or in combination, for 18 h/day, 5 days/wk for 10 mo, followed by a clean air period of up to 20 mo. Morphological studies were performed by light microscopy (LM) and transmission (TEM) and scanning electron microscopy (SEM). The main purpose of the overall study was to examine the ultrastructural features of hyperplastic bronchioloalveolar epithelium with the goal of shedding light on the range of cellular phenotypes involved. By LM on routine paraffin sections, three main types of bronchioloalveolar hyperplasia were recognized: bronchiolar type, alveolar type, and poorly differentiated/undifferentiated type. Further examination of hyperplastic foci by TEM revealed that the cellular components of the bronchiolar type of hyperplasia generally resembled those of normal bronchioles, (abstract truncated)