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Genetic effects of dioxins in the spot test with mice

: Fahrig, R.


Environmental Health Perspectives 101 (1993), No.3, pp.257-261
ISSN: 0091-6765
ISSN: 1078-0475
ISSN: 1552-9924
International Conference on Environmental Mutagenesis in Human Populations at Risk <1, 1992, Cairo>
Conference Paper
Fraunhofer ITA ( ITEM) ()
antimutagen; carcinogen; Carcinogenesis; carcinogenicity testing; cocarcinogen; dioxin; genetic recombination; genetic toxicology; genetics; mouse; mutagen; mutagenesis; mutagenicity testing; pentachlorodibenzodioxin; spot test; tetrachlorodibenzodioxin

More than any other environmental chemicals, dioxins have been in the limelight of public interest for about 10 years. In addition to carcinogenicity, genetic risk is a cause for concern. Mutagenicity tests performed so far do not give a clear picture. The mutagenic potential of dioxins has to be considered weak or absent. Therefore, it seemed profitable to investigate comutagenicity and co-recombinogenicity of dioxins more thoroughly. The only useful method for investigating comutagenicity and co-recombinogenicity of dioxins in vivo is the spot test with mice. In this test system, a number of cocarcinogens and tumor promoters have shown comutagenic or co-recombinogenic effects. In the present study, tetrachlorodibenzo-p-dioxin (TCDD) and two environmental dioxin mixtures (pentachlorodibenzodioxin - PCDD - 1 and 2) were tested for genetic activity.