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Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles

: Gallagher, J.; Heinrich, U.; George, M.; Hendee, L.; Phillips, D.H.; Lewtas, J.


Carcinogenesis 15 (1994), No.7, pp.1291-1299
ISSN: 0143-3334
Journal Article
Fraunhofer ITA ( ITEM) ()
carbon-black; carcinogenicity testing; Carcinogens; diesel motor exhaust gas; diesel soot; DNA; DNA adducts; experimental toxicology; inhalation toxicology; lung; particles; Polycyclic aromatic hydrocarbons; Polycyclic compounds; rat; respiratory organs; titanium dioxide; toxicology; tumor

Exposure of rats to diesel emissions results in the development of lung tumors. The objective of this study was to determine whether the PAHs, nitro-PAHs or other polycyclic organic matter adsorbed to diesel particles induces the formation of DNA adducts in the lung when compared to particles with little or no adsorbed organic matter. (...) Our data suggest that long-term contanct with these particles may result in a cell proliferative response, enhanced degradation of I-compounds not related to cell proliferation, and/or synthesis of I-compounds, irrespective of the differences in organic content associated with the three particle types. This response may be an important factor in explaining the reported similarity in tumorigenic response in rodents exposed to diesel emissions, carbon black and TiO2 particles.