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Formation of DNA adducts by the hydroxyanthraquinone lucidin

 

Naunyn-Schmiedebergs archives of pharmacology 343 (1991), pp.R33
ISSN: 0028-1298
ISSN: 1432-1912
Deutsche Gesellschaft für Pharmakologie und Toxikologie (Spring Meeting) <32, 1991, Mainz>
English
Conference Paper
Fraunhofer ITA ( ITEM) ()
anthraquinone; genetic toxicology; genotoxicity; hydroxyanthraquinone; lucidin; pharmacology; toxicology

Abstract
Lucidin is the genotoxic principle of madder roots. To investgate whether lucidin, indeed, interacts covalently with DNA, we incubated the compound for 3 hours with DNA of polydGpolydC and S9 mix and examined the reisolated nucleic acids by 32P-postlabelling. Similar adduct patterns, containing up to 5 spots, were obtained on PEI-cellulose tic with DNA or polydGpolydC. Formation of DNA adducts was also observed after treatment with lucidin of primary rat hepatocytes in culture. Finally, DNA adducts were detected in liver, kidney, duodenum and colon of male Parkes mice that had been treated orally for 4 days with lucidin, its glycoside lucidinprimeveroside or Rubia TeepR, a pharmaceutical preparation containing the two compounds. These results suggest that the therapeutic use of lucidin may constitute a carcinogenic risk.

: http://publica.fraunhofer.de/documents/PX-15006.html