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  4. Examination of the mononuclear phagocyte system in lupus-prone male BXSB mice
 
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1996
Journal Article
Title

Examination of the mononuclear phagocyte system in lupus-prone male BXSB mice

Abstract
During the course of lupus-like autoimmune disease male BXSB mice develop an increasing monocytosis in the periperal blood. As we demonstrated previously, this monocytosis is paralleled by an expansion of a strain-specific high number of macrophage precursor cells (CFU-M) in the bone marrow of male mice. To test the hypothesis that the expanded mononuclear phagocyte system (MPS) may promote autoimmune disease in these mice the organ-associated macrophage system was examined. Our latest data show that an unusual expansion of CFU-M also appears in spleen and liver of male mice 2 weeks after birth. In addition to a morphological alteration of the organs during the course of the disease there is a change in number and distribution of organ-resident macrophages. Considering these results the possible contribution of the expanded MPS in promoting autoimmune disease is discussed.
Author(s)
Vieten, G.
Grams, B.
Müller, M.
Hartung, K.
Emmendörffer, A.
Journal
Journal of Leukocyte Biology  
Language
English
ITA  
Keyword(s)
  • antigen

  • autoimmune disease

  • autoimmunity

  • immunology

  • macrophage

  • monocyte

  • monocytosis

  • mouse

  • phagocytosis

  • systemic lupus erythematodes

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