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Title
Enzymatische Synthese optisch aktiver Hydroxamsaeuren und ihre Umsetzung zu optisch aktiven primaeren Aminen durch Lossen-Umlagerung
Date Issued
2002
Author(s)
Patent No
1996-19620189
Abstract
Preparation of optically-active hydroxamic acid derivatives of formula (I) by: (a) reacting a racemate of a chiral amide, carboxylic acid ester or carboxylic acid of formula (II) with hydroxylamine in the presence of an acyl transferase, and (b) separating (I) from unreacted (II). R1-R3 = optionally substituted cyclic, linear, aliphatic or aromatic hydrocarbon, optionally containing heteroatoms; X =NH2, OR or OH, and R = any organic residue. Also claimed is that (I) are rearranged to give the optically-active primary amines (III) by heating in an aprotic solvent in the presence of base. USE - The optically-active hydroxamic acid derivatives (I) undergo Lossen rearrangement to give a chiral amine and hence are useful synthetic intermediates.
Language
de
Patenprio
DE 1996-19620189 A: 19960520