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The EBNA2-related resistance towards Alpha interferon -IFN-alpha- in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3

 
: Aman, P.; Decker, T.; Gabain, A. von; Kallin, B.; Kanda, K.; Wahlström, M.

Molecular and Cellular Biology 12 (1992), No.11, pp.4930-4936
ISSN: 0270-7306
English
Journal Article
Fraunhofer ITA ( ITEM) ()
antigene; biological chemistry; Burkitt's lymphoma; DNA binding protein; gene expression; genetic transcription; interferon; Lymphoma; molecular biology; Molecular genetics; regulation; transcription factor; Viral antigene

Abstract
Transfection of a plasmid encoding the Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) gene confers resistance to the antiproliferative effect of alpha interferon in EBV-negative U968 cells. We studied the expression of IFN-stimulated genes (ISGs) in two pairs of Burkitt's lymphoma cell lines, differing in the expression of the putative immortalizing gene of EBV, EBNA2. (Abstract truncated).

: http://publica.fraunhofer.de/documents/PX-10474.html