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Micro structure surface functionalisation for tissue engineering applications - A systematic integrated approach towards high volume production

: Brecher, C.; Wenzel, C.; Klar, R.; Pretzsch, F.

European Society for Precision Engineering and Nanotechnology -EUSPEN-:
European Society for Precision Engineering and Nanotechnology, EUSPEN 2008. Vol.2 : 10th Anniversary International Conference, Kongresshaus Zürich, 18th-22nd May 08
Bedford: Euspen, 2008
ISBN: 978-0-9553082-5-3
European Society for Precision Engineering and Nanotechnology (EUSPEN International Conference) <10, 2008, Zürich>
Conference Paper
Fraunhofer IPT ()
Bioreaktor; Zelle (Biologie); Tissue Engineering; Mikrostruktur; Oberflächenbeschaffenheit; Oberflächentextur; Nut; Formgießen; spanende Bearbeitung; Diamantwerkzeug; Heißprägevorrichtung

The benefits of functional matrices for in-vitro cell cultivation are well known and their application has lead to major advances in the field of tissue engineering. While three dimensional structures (scaffolds), simulating an extra cellular matrix (ECM), are essential for eventual organ replication, two dimensional, functionalized surfaces are used for cell separation and optimized cultivation of individual cell types. Aiming at high volume production of cell type specific micro structured surfaces for use in bio reactors, an interdisciplinary team of Fraunhofer researchers in the fields of biology, micro technology and precision manufacturing are working on the development of bio-functionalized surface structures and their mass replication. Micro structured surfaces are being developed, produced and systematically analyzed for their applicability with different cell types. Structure geometries include parallel grooves of various cross sections (square, round, v-shaped) as well as knob-like surface textures of different geometries and spatial distribution. Structure sizes range from multiple micro meters down to sub micro meter values. This paper will describe the conducted research and preliminary results, thereby focussing on mould making using diamond machining technologies and replication through hot embossing.