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Assessment of the molecular basis of the proallergenic effects of cigarette smoke

: Smyth, L.J.; Machado, D.C.; Upton, A.P.; Good, S.; Aufderheide, M.; Helm, B.A.


Environmental science and technology 34 (2000), No.7, pp.1370-1374
ISSN: 0013-936X
EISSN: 1520-5851
Journal Article
Fraunhofer ITA ( ITEM) ()
air pollution; allergy; Asthma; cytokine; cytotoxicity; immunoglobulins; interleukins; mast cell; tobacco smoke

Epidemiological studies indicate a link between smoking and increased risk of IgE-mediated allergies and asthma. The molecular basis underlying cigarette smoke-related respiratory disorders are ill defined, but it is known that mast cells in the mucosal lining of the airways are an important reservoir of proinflammatory mediators, which play a pivotal role in the development of these diseases. The establishment of a novel cell exposure unit facilitated a study of mast cell responses to pollutants in mainstream cigarette smoke at the air/cell interface. This study shows that cigarette smoke, but not filtered clean air, induces the release of mediators of type I hypersensitivity responses and stimulates the synthesis of proinflammatory cytokines, including interleukin (IL) 4, 5, 10, and 13 and tumor necrosis factor (TNF)-alpha, in cells of mast cell lineage. These results explain how exposure to pollutants present in cigarette smoke can induce the pathophysiological responses associated with allergy, IgE-mediated and IgE-independent asthma since IL 4 and IL 13 induce class switching to IgE, and IL 13 has recently been identified as the key mediator of IgE-independent asthma.