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Biopersistance of various types of mineral fibres in the rat lung after intratracheal application

: Bellmann, B.; Muhle, H.

British Occupational Hygiene Society -BOHS-:
Inhaled Particles VII. International Symposium on Inhaled Particles 1996. Proceedings : Cambridge, August 26 - 30, 1996
Oxford: Pergamon, 1997 (The annals of occupational hygiene 41.1997, Supplement 1)
ISBN: 0-08-042740-5
ISSN: 0003-4878
International Symposium on Inhaled Particles <8, 1996, Cambridge>
Conference Paper, Journal Article
Fraunhofer ITA ( ITEM) ()
Carcinogenesis; carcinogenicity testing; fiber; fiber - toxicology; glass fiber; intratracheal instillation; lung; man-made fiber; mineral fiber; Mineral fibers - Toxicology; polypropylene fibers; rat; toxicity testing; toxicology

Introduction: From present knowledge the biopersistence of fibres is a critical factor for the possible cancerogenic potency of these materials. To test the relationships between chemical composition, biopersistence and cancerogenicity, in the present study fibre materials were used which preferably had been already tested for carcinogenic potency in an intraperitoneal test or an inhalation study.