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A survey of nematode SmY RNAs. Editorial

 
: Jones, T.A.; Otto, W.; Marz, M.; Eddy, S.R.; Stadler, P.F.

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RNA biology 6 (2009), No.1, pp.5-8
ISSN: 1547-6286
ISSN: 1555-8584
English
Journal Article
Fraunhofer IZI ()

Abstract
SmY RNAs are a family of similar to 70-90 nt small nuclear RNAs found in nematodes. In C elegans, SmY RNAs copurify in a small ribonucleoprotein (snRNP) complex related to the SL1 and SL2 snRNPs that are involved in nematode mRNA trans-splicing. Here we describe a comprehensive computational analysis of SmY RNA homologs found in the currently available genome sequences. We identify homologs in all sequenced nematode genomes in class Chromadorea. We are unable to identify homologs in a more distantly related nematode species, Trichinella spiralis (class: Dorylaimia), and in representatives of non-nematode phyla that use trans-splicing. Using comparative RNA sequence analysis, we infer a conserved consensus SmY RNA secondary structure consisting of two stems flanking a consensus Sin protein binding site. A representative seed alignment of the SmY RNA family, annotated with the inferred consensus secondary structure, has been deposited with the Rfam, RNA families database.

: http://publica.fraunhofer.de/documents/N-89257.html