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Zellkulturträger für eine In-vitro-Permeabilitaetsuntersuchung an einer Zellschicht sowie zugehörige Verwendung

Cell culture carrier for in-vitro-permeability assay at cellular layer for certain active substance, and for measurement of electrical conductance of cellular layer before or after measurement of permeability, has two compartments
 
: Daum, N.; Katsen-Globa, A.; Lehr, C.-M.; Zimmermann, H.

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Frontpage ()

DE 102007003585 A: 20070124
DE 102007003585 A: 20070124
C12M0003
C12M0001
German
Patent, Electronic Publication
Fraunhofer IBMT ()

Abstract
(A1) Die Erfindung betrifft einen Zellkulturtraeger (2) fuer eine In-vitro-Permeabilitaetsuntersuchung an einer Zellschicht (8), mit einem ersten Kompartiment (3), einem zweiten Kompartiment (4), einer zwischen dem ersten Kompartiment (3) und dem zweiten Kompartiment (4) angeordneten permeablen Membran (7) zur Aufnahme der zu untersuchenden Zellschicht (8) sowie mit einer baulich integrierten Messelektrodenanordnung (9, 10) zur Messung des elektrischen Durchgangswiderstands der zu untersuchenden Zellschicht (8) auf der permeablen Membran (7).

 

DE 102007003585 A1 UPAB: 20081002 NOVELTY - The cell culture carrier (2) has two compartments, and a permeable membrane between the both compartments for the supporting the cellular layer (8) to be examined. A structurally integrated measuring electrode system (9,10) is also provided for the measurement of the electrical conductance of the cellular layer, to be examined onto the permeable membrane. The former compartment is molded cup-shaped. An impermeable side wall and the permeable membrane have bottom. Former compartment is inserted into the later compartment. USE - Cell cultural carrier for an in-vitro-permeability assay at a cellular layer, for measurement of the permeability of the cellular layer for a certain active substance, and measurement of the electrical conductance of the cellular layer before and/or after the measurement of the permeability (all claimed). ADVANTAGE - The cell culture carrier ensures integrity of the cellular layer, has improved quality, and is not damage by the electrode arrangement.

: http://publica.fraunhofer.de/documents/N-86282.html