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A probabilistic approach to classifying metabolic stability

: Schwaighofer, A.; Schröter, T.; Mika, S.; Hansen, K.; Laak, A. ter; Lienau, P.; Reichel, A.; Heinrich, N.; Müller, K.-R.


Journal of chemical information and modeling 48 (2008), No.4, pp.785-796
ISSN: 1549-9596
ISSN: 0095-2338
EISSN: 1520-5142
Journal Article
Fraunhofer FIRST ()

Metabolic stability is an important property of drug molecules that should-optimally-be taken into account early on in the drug design process. Along with numerous medium- or high-throughput assays being implemented in early drug discovery, a prediction tool for this property could be of high value. However, metabolic stability is inherently difficult to predict, and no commercial tools are available for this purpose. In this work, we present a machine learning approach to predicting metabolic stability that is tailored to compounds from the drug development process at Bayer Schering Pharma. For four different in vitro assays, we develop Bayesian classification models to predict the probability of a compound being metabolically stable. The chosen approach implicitly takes the "domain of applicability" into account. The developed models were validated on recent project data at Bayer Schering Pharma, showing that the predictions are highly accurate and the domain of applicability is estimated correctly. Furthermore, we evaluate the modeling method on a set of publicly available data.