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Implantable biomedical microsystems for neural prostheses

Flexible, polyimide-based modular implantable biomedical microsystems for neural prostheses
: Stieglitz, T.; Koch, K.P.; Schüttler, M.


IEEE engineering in medicine and biology magazine 24 (2005), No.5, pp.58-65
ISSN: 0278-0054
ISSN: 0739-5175
Journal Article
Fraunhofer IBMT ()

In the following article, the technologies to fabricate polyimide-based thin and flexible substrates with monolithically integrated electrode arrays and printed circuit boards (PCB) for hybrid electronic assemblies as well as an assembling technique that connects bare electronic dice with flexible PCBs are presented. The concept of modular, flexible biomedical microsystems as neural prostheses is introduced in general and described in detail in three examples. A cuff electrode with integrated multiplexer circuitry and standard implantable cables represents the combination of microtechnology with precision mechanics; a sieve electrode used as an implant in peripheral nerve regeneration studies demonstrates the next level of integration density but still uses a cable connection; and last, joint effort to fabricate the demonstrator of a vision prosthesis that is completely implantable in the eye with a wireless link for energy supply and data transmission is presented. System design, hybrid assembling technology, and flexible multilayer encapsulation using parylene and silicone rubber are the key components for creating a new generation of neural prostheses for complex and challenging new applications.