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2020
Conference Paper
Titel
CTO: A community-based clinical trial ontology and its applications in PubChemRDF and SCAIView
Abstract
Driven by the use cases of PubChemRDF and SCAIView, we have developed a first community-based clinical trial ontology (CTO) by following the OBO Foundry principles. CTO uses the Basic Formal Ontology (BFO) as the top level ontology and reuses many terms from existing ontologies. CTO has also defined many clinical trial-specific terms. The general CTO design pattern is based on the PICO framework together with two applications. First, the PubChemRDF use case demonstrates how a drug Gleevec is linked to multiple clinical trials investigating Gleevecâs related chemical compounds. Second, the SCAIView text mining engine shows how the use of CTO terms in its search algorithm can identify publications referring to COVID-19-related clinical trials. Future opportunities and challenges are discussed.
Author(s)
Li, Q.L.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Bolton, E.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Project(s)
HBP SGA2
Funder
European Commission EC
European Commission EC
File(s)
Externer Link
Language
English