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Novel cost-efficient graphene-based impedance biosensor for the analysis of viral cytopathogenicity and the effect of antiviral drugs

: Schultz, Anke; Knoll, Thorsten; Urban, Andreas; Schuck, Herbert; Briesen, Hagen von; Germann, Anja; Velten, Thomas

Fulltext urn:nbn:de:0011-n-6384945 (6.7 MByte PDF)
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Created on: 3.8.2021

Frontiers in Bioengineering and Biotechnology 9 (2021), Art. 718889, 10 pp.
ISSN: 2296-4185
Journal Article, Electronic Publication
Fraunhofer IBMT ()

Biosensors become increasingly relevant for medical diagnostics, pharmaceutical industry, and environmental technology, for example, to test new drugs easily and reliably or to detect cell growth in changing environmental conditions. Novel materials like graphene are promising candidates to produce biosensors on an industrial scale by means of printing processes. To reach this aim, methods for the reliable and automated production of electrode structures and their coating are required. We present an impedance biosensor in the format of a microtiter plate, fabricated by highly efficient roll-to-roll printing of graphene-based microstructures on large-area polymer foils. Proof-of-principle experiments show the evidence of the suitability of the printed graphene biosensors for impedance-based monitoring of viral cytopathogenicity and its inhibition in the presence of antiviral drugs. The developed system is a promising approach toward cost-efficient impedimetric biosensors for high-throughput screening in vaccine research and antiviral drug development.