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Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

: Wirth, A.; Wolf, B.; Huang, C.-K.; Glage, S.; Hofer, S.J.; Bankstahl, M.; Bär, C.; Thum, T.; Kahl, K.G.; Sigrist, S.J.; Madeo, F.; Bankstahl, J.P.; Ponimaskin, E.

Fulltext ()

GeroScience 43 (2021), No.2, pp.673-690
ISSN: 2509-2715
ISSN: 2509-2723
Journal Article, Electronic Publication
Fraunhofer ITEM ()

Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration.